経歴

学術雑誌等に発表した論文、著書

1. Javad Rasouli, Giacomo Casella, Satoshi Yoshimura, Weifeng Zhang, Dan Xiao,James Garifallou, Michael V Gonzalez, Alice Wiedeman, Anna Kus, Elisabeth R Mari, Paolo Fortina, Hakon Hakonarson, S Alice Long, Guang-Xian Zhang, Bogoljub Ciric, Abdolmohamad Rostami. A distinct GM-CSF+ T helper cell subset requires T-bet to adopt a TH1 phenotype and promote neuroinflammation. Sci Immunol 5(52) : eaba9953, 2020.
2. Yoshimura S, Thome R, Konno S, Mari ER, Rasouli J, Hwang D, Boehm A, Li Y, Zhang GX, Ciric B, Rostami A. IL-9 Controls Central Nervous System Autoimmunity by Suppressing GM-CSF Production. J Immunol 204(3): 531-539, 2020
3. Thome R, Moore JN, Mari ER, Rasouli J, Hwang D, Yoshimura S, Ciric B, Zhang GX, Rostami AM. Induction of Peripheral Tolerance in Ongoing Autoimmune Inflammation Requires Interleukin 27 Signaling in Dendritic Cells. Front Immunol 8: 1392, 2017
4. Nakamura Y, Takase KI, Matsushita T, Yoshimura S, Yamasaki R, Murai H, Kikuchi K, Kira JI. Recurrent Hemorrhagic Venous Infarctions Caused by Thrombosis of a Pontine Developmental Venous Anomaly and Protein S Mutation. J Stroke Cerebrovasc Dis 25(11): e216-e217, 2016
5. Nakamura Y, Matsushita T, Sato S, Niino M, Fukazawa T, Yoshimura S, Hisahara S, Isobe N, Shimohama S, Watanabe M, Yoshida K, Houzen H, Miyazaki Y, Yamasaki R, Kikuchi S, Kira J; Japan Multiple Sclerosis Genetics Consortium. Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study. J Neuroinflammation 13(1): 239, 2016
6. Saigoh K, Yoshimura S, Izumikawa T, Miyata S, Tabara Y, Matsushita T, Miki T, Miyamoto K, Hirano M, Kitagawa H, Kira JI, Kusunoki S. Chondroitin sulfate β-1,4-N-acetylgalactosaminyltransferase-1 (ChGn-1) polymorphism: Association with progression of multiple sclerosis. Neurosci Res 108: 55-59, 2016
7. Sato S, Yamamoto K, Matsushita T, Isobe N, Kawano Y, Iinuma K, Niino M, Fukazawa T, Nakamura Y, Watanabe M, Yonekawa T, Masaki K, Yoshimura S, Murai H, Yamasaki R, Kira J; Japan Multiple Sclerosis Genetics Consortium. Copy number variations in multiple sclerosis and neuromyelitis optica. Ann Neurol 78: 762-74, 2016
8. Niino M, Sato S, Fukazawa T, Yoshimura S, Hisahara S, Matsushita T, Isobe N, Yoshida K, Houzen H, Miyazaki Y, Shimohama S, Kikuchi S, Kira JI: Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis. Mult Scler 21: 1112-1120, 2015
9. Noriko Isobe, Tomomi Yonekawa, Takuya Matsushita, Yuji Kawano, Katsuhisa Masaki, Satoshi Yoshimura, Hiroyuki Murai, Ryo Yamasaki and Jun-ichi Kira. Distinct features of immunoglobulin G2 aquaporin-4 antibody carriers with neuromyelitis optica. Clinical and Experimental Neuroimmunology 6:154-158, 2015
10. Yoshimura S. The genetics of multiple sclerosis and neuromyelitis optica in Japan. J Neurol Disord Stroke 2(4): 1079, 2014
11. Hikaru Doi, Zi-Ye Song, Satoshi Yoshimura, Takahisa Tateishi, Tomomi Yonekawa, Ryo Yamasaki, Hiroyuki Murai, Takuya Matsushita and Jun-ichi Kira. Distinct cytokine and T helper cell profiles between patients with multiple sclerosis who had or had not received interferon-beta. Clinical and Experimental Neuroimmunology 5:321-327, 2014
12. Yoshimura S, Isobe N, Matsushita T, Masaki K, Sato S, Kawano Y, Ochi H, Kira J. Genetic and Infectious Profiles Influence Cerebrospinal Fluid IgG Abnormality in Japanese Multiple Sclerosis Patients. PLoS One 9:e95367, 2014
13. Ainiding G, Kawano Y, Sato S, Isobe N, Matsushita T, Yoshimura S, Yonekwa T, Yamasaki R, Murai H, Kira J; South Japan Multiple Sclerosis Genetic Consortium. Interleukin 2 receptor α chain gene polymorphisms and risks of multiple sclerosis and neuromyelitis optica in southern Japanese. J Neurol Sci 337(1-2): 147-150, 2014
14. Yoshimura S, Yonekawa T, Isobe N, Matsushita T, Kira J. Bacterial infectious burden and prevalence of idiopathic central nervous system demyelinating diseases in Japanese. Clinical and Experimental Neuroimmunology 4: 351?352, 2013
15. Saitoh BY, Yamasaki R, Hayashi S, Yoshimura S, Tateishi T, Ohyagi Y, Murai H, Iwaki T, Yoshida K, Kira J. A case of hereditary diffuse leukoencephalopathy with axonal spheroids caused by a de novo mutation in CSF1R masquerading as primary progressive multiple sclerosis. Mult Scler 19: 1367-1370, 2013
16. Kira J, Yamasaki R, Yoshimura S, Fukazawa T, Yokoyama K, Fujihara K, Ogino M, Yokota T, Miyamoto K, Niino M, Nomura K, Tomioka R, Tanaka M, Kawachi I, Ohashi T, Kaida K, Matsui M, Nakatsuji Y, Ochi H, Fukaura H, Kanda T, Nagaishi A, Togo K, Mizusawa H, Kawano Y. Efficacy of methylprednisolone pulse therapy for acute relapse in Japanese patients with multiple sclerosis and neuromyelitis optica: A multicenter retrospective analysis ? 1. Whole group analysis. Clinical and Experimental Neuroimmunology 4: 305?317, 2013
17. Kawano Y, Matsushita T, Cui Y, Isobe N, Yoshimura S, Yonekawa T, Masaki K, Yamasaki R, Murai H, Kira J. Protein kinase C-η polymorphism rs2230500 does not confer disease susceptibility to multiple sclerosis or neuromyelitis optica. Clinical and Experimental Neuroimmunology 4: 283?287, 2013
18. Huang J, Isobe N, Matsushita T, Yoshimura S, Sato S, Yonekawa T, Yamasaki R, Murai H, Kira J; South Japan Multiple Sclerosis Consortium. Distinct genetic profiles between Japanese multiple sclerosis patients with and without Barkhof brain lesions. Clinical and Experimental Neuroimmunology 4: 173?180, 2013
19. Huang J, Yoshimura S, Isobe N, Matsushita T, Yonekawa T, Sato S, Yamasaki R, Kira J; South Japan Multiple Sclerosis Consortium. A NOTCH4 missense mutation confers resistance to multiple sclerosis in Japanese. Mult Scler 19: 1696-1703, 2013
20. Isobe N, Yonekawa T, Matsushita T, Masaki K, Yoshimura S, Fichna J, Chen S, Furmaniak J, Smith BR, Kira J. Clinical relevance of serum aquaporin-4 antibody levels in neuromyelitis optica. Neurochem Res 38: 997-1001, 2013
21. Yoshimura S, Isobe N, Matsushita T, Yonekawa T, Masaki K, Sato S, Kawano Y, Kira J; South Japan Multiple Sclerosis Genetics Consortium. Distinct genetic and infectious profiles in Japanese neuromyelitis optica patients according to anti-aquaporin 4 antibody status. J Neurol Neurosurg Psychiatry 84: 29-34, 2013
22. Yoshimura S, Isobe N, Yonekawa T, Matsushita T, Masaki K, Sato S, Kawano Y, Yamamoto K, Kira J; South Japan Multiple Sclerosis Genetics Consortium. Genetic and infectious profiles of Japanese multiple sclerosis patients. PLoS One. 7: e48592, 2012
23. Sato S, Isobe N, Yoshimura S, Kanamori Y, Masaki K, Matsushita T, Kira J. HLA-DPB1*0201 is associated with susceptibility to atopic myelitis in Japanese. J Neuroimmunology 251(1-2): 110-113, 2012
24. Isobe N, Yonekawa T, Matsushita T, Kawano Y, Masaki K, Yoshimura S, Fichna J, Chen S, Furmaniak J, Smith BR, Kira J. Quantitative assays for anti-aquaporin-4 antibody with subclass analysis in neuromyelitis optica. Mult Scler 18: 1541-1551, 2012
25. Yonekawa T, Matsushita T, Minohara M, Isobe N, Masaki K, Yoshimura S, Nishimura S, Kira J. T cell reactivities to myelin protein-derived peptides in neuromyelitis optica patients with anti-aquaporin-4 antibody. Neurology Asia 16: 139-142, 2011
26. Fang L, Isobe N, Yoshimura S, Yonekawa T, Matsushita T, Masaki K, Doi H, Ochi K, Miyamoto K, Kawano Y, Kira J. South Japan Multiple Sclerosis Genetics Consortium. Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians. Neurology 76: 2125-2127, 2011
27. Yoshimura S, Ochi H, Isobe N, Matsushita T, Motomura K, Matsuoka T, Minohara M, Kira J. Altered production of brain-derived neurotrophic factor by peripheral blood immune cells in multiple sclerosis. Mult Scler 16: 1178-1188, 2010

学術雑誌等又は商業誌における解説、総説

1. 吉村怜：疾患感受性遺伝子・疾患抵抗性遺伝子. アクチュアル 脳・神経疾患の臨床. 免疫性神経疾患　病態と治療のすべて 中山書店 pp, 2016
2. 吉村怜：多発性硬化症と視神経脊髄炎　環境因子－感染性因子の寄与－.日本臨床 72(11):1930-1934, 2014
3. 松下拓也, 吉村怜, 小副川学, 吉良潤一. 第4回多発性硬化症全国臨床疫学調査による日本における多発性硬化症の治療実態の解析. 神経治療学 30(1):67-70, 2013
4. 吉村怜, 吉良潤一：ステロイドの使い方 多発性硬化症. ステロイド診療マニュアル 新興医学出版社 pp122-130, 2013
5. 吉村怜：多発性硬化症の病態と治療－免疫遺伝学的背景からみた病因・病態. アクチュアル 脳・神経疾患の臨床 最新アプローチ 多発性硬化症と視神経脊髄炎 中山書店 pp119-124, 2012
6. 吉村怜, 吉良潤一：｢新薬展望2013｣ 免疫抑制剤　多発性硬化症におけるフィンゴリモド塩酸塩の治療効果と課題. 医薬ジャーナル 49(S-1):115-123, 2013
7. 吉村怜, 吉良潤一：最新の神経難病治療と今後の展望 多発性硬化症とNMO．医薬ジャーナル 48:79-85, 2012
8. 吉村怜, 吉良潤一．多発性硬化症の疫学　―全国臨床疫学調査からみえてきたもの―. 医学のあゆみ「多発性硬化症と視神経脊髄炎」237:284-290, 2011
9. 吉村怜, 吉良潤一. MS (多発性硬化症)に対するクラドリビン治療. BIO Clinia 25(10):64-67, 2010
10. 吉村怜, 村井弘之, 吉良潤一. 急性散在性脳脊髄炎, EBMに基づく脳神経疾患の基本治療指針(改訂第3版), pp410-412, 2010
11. 吉村怜, 吉良潤一. 多発性硬化症におけるステロイド療法の実際, Modern Physician 29:635-639, 2009
12. 吉村怜, 重藤寛史, 野村拓夫, 大八木保政, 吉良潤一. 上方注視麻痺を呈した一側視床梗塞症例においてMRI T2強調画像矢状断で判明したriMLF病変. 神経内科65(1):94-9, 2006

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